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And lastly, clonidine boosts neuraxial opioids and, together with fentanyl, interacts in an additive way, which often can lessen the dose of each part by sixty% for postoperative analgesia.Jun ten, 2024 · If clonidine therapy is to be replaced by a ?-blocker, hold off administration with the ?-blocker for many days soon after clonidine therapy is… Read More